Article
Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas.
Nature - 20 Jan 1994
Woronicz J D, Calnan B, Ngo V, Winoto A
Abstract excerpt
Apoptosis is a phenomenon observed during development of many cell types in many organisms. It is an internal, programmed cell death characterized by DNA fragmentation into nucleosome-size pieces. Anti-CD3-induced apoptosis in T-cell hybridomas and immature thymocytes requires new gene transcription and may be related to negative selection during T-cell development. Using subtractive hybridization, we isolated a...
Topics
- Apoptosis
- DNA-Binding Proteins
- Hybridomas
- Mutation
- Nuclear Receptor Subfamily 4, Group A, Member 1
- Receptors, Cytoplasmic and Nuclear
- Receptors, Steroid
- T-Lymphocytes
- Transcription Factors