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Article

Dephosphorylation and caspase processing generate distinct nuclear pools of histone deacetylase 4.

Molecular and cellular biology - 1 Oct 2007

Paroni Gabriela, Fontanini Alessandra, Cernotta Nadia, Foti Carmela, Gupta Mahesh P, Yang Xiang-Jiao, Fasino Dario, Brancolini Claudio

Abstract excerpt

From the nucleus, histone deacetylase 4 (HDAC4) regulates a variety of cellular processes, including growth, differentiation, and survival, by orchestrating transcriptional changes. Extracellular signals control its repressive influence mostly through regulating its nuclear-cytoplasmic shuttling. In particular, specific posttranslational modifications such as phosphorylation and caspase-mediated proteolytic...

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Identifiers

PMID: 17636017
DOI: 10.1128/MCB.00853-07
PMCID: PMC2099224

Genes

HDAC4
SRF
HDAC5

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