Article
Mechanism for nucleocytoplasmic shuttling of histone deacetylase 7.
The Journal of biological chemistry - 14 Dec 2001
Kao H Y, Verdel A, Tsai C C, Simon C, Juguilon H, Khochbin S
Abstract excerpt
Here we show that HDAC7, a member of the class II histone deacetylases, specifically targets several members of myocyte enhancer factors, MEF2A, -2C, and -2D, and inhibits their transcriptional activity. Furthermore, we demonstrate that DNA-bound MEF2C is capable of recruiting HDAC7, demonstrating that the HDAC7-dependent repression of transcription is not due to the inhibition of the MEF2 DNA binding activity....
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