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Article

Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7.

Proceedings of the National Academy of Sciences of the United States of America - 3 Jun 2008

Wang Shusheng, Li Xiumin, Parra Maribel, Verdin Eric, Bassel-Duby Rhonda, Olson Eric N

Abstract excerpt

VEGF has been shown to regulate endothelial cell (EC) proliferation and migration. However, the nuclear mediators of the actions of VEGF in ECs have not been fully defined. We show that VEGF induces the phosphorylation of three conserved serine residues in histone deacetylase 7 (HDAC7) via protein kinase D, which promotes nuclear export of HDAC7 and activation of VEGF-responsive genes in ECs. Expression of a...

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Share to Active Transport, Cell Nucleus
Share to Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Intercellular Signaling Peptides and Proteins

Share to Neovascularization, Physiologic

Share to Protein Kinase C

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Share to Vascular Endothelial Growth Factor A

Source

Open in PubMed Open full text

Identifiers

PMID: 18509061
DOI: 10.1073/pnas.0802857105
PMCID: PMC2409381

Genes

HDAC7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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