An inner-pore mutation (F315D) promotes intracellular Mg2+ block and inward rectification of BK channels.

doi:10.1016/j.bbamem.2026.184558

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Article

An inner-pore mutation (F315D) promotes intracellular Mg2+ block and inward rectification of BK channels.

Biochimica et biophysica acta. Biomembranes - 1 Oct 2026

Sekrecka-Belniak Anna, Koprowski Piotr, Bednarczyk Piotr, Dworakowska Beata

Abstract excerpt

Large-conductance Ca2+- and voltage-activated potassium (BK) channels display a near-linear current-voltage relationship in excised membrane patches but exhibit inward rectification in intact cells due to block by intracellular cations. This rectification arises from electrostatic interactions between endogenous cationic blockers and negatively charged residues lining the inner pore. Here, we examined how the...

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PMID: 42448260
DOI: 10.1016/j.bbamem.2026.184558

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