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Article

The NH2 terminus of RCK1 domain regulates Ca2+-dependent BK(Ca) channel gating.

The Journal of general physiology - 1 Sept 2005

Krishnamoorthy Gayathri, Shi Jingyi, Sept David, Cui Jianmin

Abstract excerpt

Large conductance, voltage- and Ca2+-activated K+ (BK(Ca)) channels regulate blood vessel tone, synaptic transmission, and hearing owing to dual activation by membrane depolarization and intracellular Ca2+. Similar to an archeon Ca2+-activated K+ channel, MthK, each of four alpha subunits of BK(Ca) may contain two cytosolic RCK domains and eight of which may form a gating ring. The structure of the MthK channel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16103277
DOI: 10.1085/jgp.200509321
PMCID: PMC2266574

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The NH2 terminus of RCK1 domain regulates Ca2+-dependent BK(Ca) channel gating.PMID 16103277Read ↗

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Calcium activation of BK(Ca) potassium channels lacking the calcium bowl and RCK domains.Semantic proximity Read ↗

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Homology modeling identifies C-terminal residues that contribute to the Ca2+ sensitivity of a BKCa channel.Semantic proximity Read ↗

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