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Article

Effects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channels.

The Journal of general physiology - 1 Jan 2006

Hu Lei, Yang Huanghe, Shi Jingyi, Cui Jianmin

Abstract excerpt

BK channels are activated by physiological concentrations of intracellular Ca2+ and Mg2+ in a variety of cells. Previous studies have identified two sites important for high-affinity Ca2+ sensing between [Ca2+]i of 0.1-100 microM and a site important for Mg2+ sensing between [Mg2+]i of 0.1-10 mM. BK channels can be also activated by Ca2+ and Mg2+ at concentrations>10 mM so that the steady-state conductance and...

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Identifiers

PMID: 16344323
DOI: 10.1085/jgp.200509317
PMCID: PMC2151482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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