Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of intratumoral genetic heterogeneity during colorectal cancer progression.

Carcinogenesis - 1 May 2005

Losi Lorena, Baisse Bénédicte, Bouzourene Hanifa, Benhattar Jean

Abstract excerpt

Evolution of intratumoral genetic heterogeneity during colorectal tumor progression has not been investigated so far. Multiple sample areas in colorectal adenocarcinoma at early and advanced stages and in metastases were studied for the well-known genetic alterations: K-ras and p53 point mutations and loss of heterozygosity (LOH) on chromosomes 5q and 18q. In primary colorectal cancers (CRCs), intratumoral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Heterogeneity

Share to Loss of Heterozygosity

Share to Mutation

Share to Neoplasm Metastasis

Share to ras Proteins

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 15731168
DOI: 10.1093/carcin/bgi044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of intratumoral genetic heterogeneity during colorectal cancer progression.PMID 15731168Read ↗

Intratumor genetic heterogeneity in advanced human colorectal adenocarcinoma.Semantic proximity Read ↗

Intratumor heterogeneity of k-ras and p53 mutations among human colorectal adenomas containing early cancer.Semantic proximity Read ↗

Intratumor Heterogeneity of k-ras and p53 Mutations Among Human Colorectal Adenomas Containing Early CancerSemantic proximity Read ↗

Intratumor heterogeneity: A new perspective on colorectal cancer research.Semantic proximity Read ↗

Intratumoral morphological heterogeneity can be an indicator of genetic heterogeneity in colorectal cancer.Semantic proximity Read ↗

Dynamics of cancer cell subpopulations in primary and metastatic colorectal tumors.Semantic proximity Read ↗

Distribution of genetic variants in preneoplastic areas of colorectal tumours.Semantic proximity Read ↗

Molecular clonality analysis of esophageal adenocarcinoma by multiregion sequencing of tumor samples.Semantic proximity Read ↗

Genetic alterations in colorectal cancer: implications for the prognosis and treatment of the disease.Semantic proximity Read ↗

Intratumoral genetic heterogeneity in Barrett adenocarcinoma.Semantic proximity Read ↗

Evidence of heterogeneity within colorectal liver metastases for allelic losses, mRNA level expression and in vitro response to chemotherapeutic agents.Semantic proximity Read ↗

Histochemical and immunohistochemical evidence of tumor heterogeneity in colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.