Article
Genetic alterations in colorectal cancer: implications for the prognosis and treatment of the disease.
Revista espanola de enfermedades digestivas - 1 Sept 2020
Del Carmen Sofía, Sayagués José María, Abad Mar
Abstract excerpt
In recent years, important advances have been achieved in the understanding of the genetic abnormalities present in colorectal tumors and their association with their ontogeny and progression. Accordingly, while the presence of mutations in the APC and/or KRAS genes is associated with neoplastic transformation, mutations in SMAD and DCC, different chromosomal abnormalities located at 7, 17p and 18q, and complex...
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