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Article

Intratumor heterogeneity of k-ras and p53 mutations among human colorectal adenomas containing early cancer.

Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology - 1 Jan 2000

Giaretti W, Rapallo A, Sciutto A, Macciocu B, Geido E, Hermsen M A, Postma C, Baak J P, Williams R A, Meijer G A

Abstract excerpt

The molecular pathways and the timing of genetic events during human colorectal carcinogenesis are still not fully understood. We have addressed the intratumor heterogeneity of the mutational status of the k-ras oncogene and of the p53 oncosuppressor gene during the adenoma-carcinoma sequence by investigating 26 human colorectal adenomas containing early cancer. An intratumor comparative analysis was obtained...

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Identifiers

PMID: 11310641
DOI: 10.1155/2000/747524
PMCID: PMC4615987

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Source receipt: pubmed, retrieved 7 Sept 2026.

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