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Article

Evidence of heterogeneity within colorectal liver metastases for allelic losses, mRNA level expression and in vitro response to chemotherapeutic agents.

International journal of cancer - 1 Sept 2010

Goasguen Nicolas, de Chaisemartin Cecile, Brouquet Antoine, Julié Catherine, Prevost Gregoire P, Laurent-Puig Pierre, Penna Christophe

Abstract excerpt

A goal of oncology is to predict chemosensitivity of tumors. This approach assumes that in a patient all tumor deposits are homogeneous. We have tested the heterogeneity between several samples of the same liver metastasis (LM; intrametastatic heterogeneity) or between multiple LM (intermetastatic heterogeneity) from colorectal cancer in a single patient. In 16 untreated patients, several fragments of LM and...

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Source

Identifiers

PMID: 20017140
DOI: 10.1002/ijc.25114

Genes

CES2
ERCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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