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Article

Molecular clonality analysis of esophageal adenocarcinoma by multiregion sequencing of tumor samples.

BMC research notes - 4 Apr 2017

van Nistelrooij Anna M J, van Marion Ronald, Koppert Linetta B, Biermann Katharina, Spaander Manon C W, Tilanus Hugo W, van Lanschot J Jan B, Wijnhoven Bas P L, Dinjens Winand N M

Abstract excerpt

BACKGROUND: Intratumor heterogeneity has been demonstrated in several cancer types, following a model of branched evolution. It is unknown to which extent intratumor heterogeneity is applicable to esophageal adenocarcinoma. Therefore the aim of this study was to characterise intratumor heterogeneity in esophageal adenocarcinoma. METHODS: Multiregional targeted sequencing of four commonly altered genes was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28376920
DOI: 10.1186/s13104-017-2456-5
PMCID: PMC5379534

Genes

APC
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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