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Article

Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.

Proceedings of the National Academy of Sciences of the United States of America - 23 Aug 2016

Chinthalapudi Krishna, Rangarajan Erumbi S, Brown David T, Izard Tina

Abstract excerpt

The main cause of death globally remains debilitating heart conditions, such as dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), which are often due to mutations of specific components of adhesion complexes. Vinculin regulates these complexes and plays essential roles in intercalated discs that are necessary for muscle cell function and coordinated movement and in the development and function...

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Share to Phosphatidylinositol 4,5-Diphosphate
Share to Protein Conformation, alpha-Helical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27503891
DOI: 10.1073/pnas.1600702113
PMCID: PMC5003255

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.PMID 27503891Read ↗

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A missense mutation in a ubiquitously expressed protein, vinculin, confers susceptibility to hypertrophic cardiomyopathy.Semantic proximity Read ↗

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