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Article

SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast.

Molecular and cellular biology - 1 Sept 1999

Page M F, Carr B, Anders K R, Grimson A, Anderson P

Abstract excerpt

mRNAs that contain premature stop codons are selectively degraded in all eukaryotes tested, a phenomenon termed "nonsense-mediated mRNA decay" (NMD) or "mRNA surveillance." NMD may function to eliminate aberrant mRNAs so that they are not translated, because such mRNAs might encode deleterious polypeptide fragments. In both yeasts and nematodes, NMD is a nonessential system. Mutations affecting three yeast UPF...

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Source

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Identifiers

PMID: 10454541
DOI: 10.1128/MCB.19.9.5943
PMCID: PMC84455

Genes

UPF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast.PMID 10454541Read ↗

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SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway.Semantic proximity Read ↗

SMG1:SMG8:SMG9-complex integrity maintains robustness of nonsense-mediated mRNA decaySemantic proximity Read ↗

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A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD.Semantic proximity Read ↗

Characterization of the mIF4G domains in the RNA surveillance protein Upf2Semantic proximity Read ↗

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