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Article

Structure of a trapped intermediate of calmodulin: calcium regulation of EF-hand proteins from a new perspective.

Journal of molecular biology - 11 Mar 2005

Grabarek Zenon

Abstract excerpt

Calmodulin (CaM) is a multifunctional Ca2+-binding protein that regulates the activity of many enzymes in response to changes in the intracellular Ca2+ concentration. There are two globular domains in CaM, each containing a pair of helix-loop-helix Ca2+-binding motifs called EF-hands. Ca2+-binding induces the opening of both domains thereby exposing hydrophobic pockets that provide binding sites for the target...

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Identifiers

PMID: 15713486
DOI: 10.1016/j.jmb.2005.01.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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