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Article

Mechanism of direct coupling between binding and induced structural change in regulatory calcium binding proteins.

Biochemistry - 15 Apr 1997

Gagné S M, Li M X, Sykes B D

Abstract excerpt

The structural transition in troponin C induced by the binding of two calcium ions involves an "opening" of the structure, an event that triggers skeletal muscle contraction. We have solved the solution structure of a mutant (E41A) of the regulatory domain of skeletal troponin C wherein one bidentate ligand to the calcium in site I is missing. This structure remains "closed" upon calcium binding, indicating that...

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PMID: 9109645
DOI: 10.1021/bi963076+

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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