Article
The Crystal Structure of Calmodulin Bound to the Cardiac Ryanodine Receptor (RyR2) at Residues Phe4246-Val4271 Reveals a Fifth Calcium Binding Site.
Biochemistry - 13 Apr 2021
Yu Qinhong, Anderson David E, Kaur Ramanjeet, Fisher Andrew J, Ames James B
Abstract excerpt
Calmodulin (CaM) regulates the activity of a Ca2+ channel known as the cardiac ryanodine receptor (RyR2), which facilitates the release of Ca2+ from the sarcoplasmic reticulum during excitation-contraction coupling in cardiomyocytes. Mutations that disrupt this CaM-dependent channel inactivation result in cardiac arrhythmias. RyR2 contains three different CaM binding sites: CaMBD1 (residues 1940-1965), CaMBD2...
Topics
- Calmodulin
- Ryanodine Receptor Calcium Release Channel
- Phenylalanine
- Valine
- Calcium
- Binding Sites
- Humans
- Cryoelectron Microscopy
- Crystallization
- Protein Binding
- Mutation