Article
The EF-hand domain: a globally cooperative structural unit.
Protein science : a publication of the Protein Society - 1 Feb 2002
Nelson Melanie R, Thulin Eva, Fagan Patricia A, Forsén Sture, Chazin Walter J
Abstract excerpt
EF-hand Ca(2+)-binding proteins participate in both modulation of Ca(2+) signals and direct transduction of the ionic signal into downstream biochemical events. The range of biochemical functions of these proteins is correlated with differences in the way in which they respond to the binding of Ca(2+). The EF-hand domains of calbindin D(9k) and calmodulin are homologous, yet they respond to the binding of calcium...
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