Article
Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca2+ binding and cause misfolding.
The Journal of physiology - 1 Mar 2020
Wang Kaiqian, Brohus Malene, Holt Christian, Overgaard Michael Toft, Wimmer Reinhard, Van Petegem Filip
Abstract excerpt
KEY POINTS: Mutations in the calmodulin protein (CaM) are associated with arrhythmia syndromes. This study focuses on understanding the structural characteristics of CaM disease mutants and their interactions with the voltage-gated calcium channel CaV 1.2. Arrhythmia mutations in CaM can lead to loss of Ca2+ binding, uncoupling of Ca2+ binding cooperativity, misfolding of the EF-hands and altered affinity for the...
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