Article
Dynamics of the transition between open and closed conformations in a calmodulin C-terminal domain mutant.
Structure (London, England : 1993) - 7 Mar 2001
Evenäs J, Malmendal A, Akke M
Abstract excerpt
BACKGROUND: Calmodulin is a ubiquitous Ca(2+)-activated regulator of cellular processes in eukaryotes. The structures of the Ca(2+)-free (apo) and Ca(2+)-loaded states of calmodulin have revealed that Ca(2+) binding is associated with a transition in each of the two domains from a closed to an open conformation that is central to target recognition. However, little is known about the dynamics of this...
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