Article
Ca2+ binding in proteins of the calmodulin superfamily: cooperativity, electrostatic contributions and molecular mechanisms.
Ciba Foundation symposium - 1 Jan 1991
Forsén S, Linse S, Drakenberg T, Kördel J, Akke M, Sellers P, Johansson C, Thulin E, Andersson I, Brodin P
Abstract excerpt
In a large number of intracellular regulatory proteins of the calmodulin superfamily a pair of closely interacting helix-loop-helix Ca2+ binding sites ('EF hands') constitute the functional unit--an arrangement that enables cooperative binding. We have recently made detailed experimental studies...
Topics
- Amides
- Binding Sites
- Calbindins
- Calcium
- Calmodulin
- Models, Molecular
- Multigene Family
- Mutation
- Peptide Fragments
- Protein Conformation
- Protons
- S100 Calcium Binding Protein G
- Solutions
- Trypsin