Article
Selective down-regulation of the NKG2D ligand H60 by mouse cytomegalovirus m155 glycoprotein.
Journal of virology - 1 Mar 2005
Hasan Milena, Krmpotic Astrid, Ruzsics Zsolt, Bubic Ivan, Lenac Tihana, Halenius Anne, Loewendorf Andrea, Messerle Martin, Hengel Hartmut, Jonjic Stipan, Koszinowski Ulrich H
Abstract excerpt
Both human and mouse cytomegaloviruses (CMVs) encode proteins that inhibit the activation of NK cells by down-regulating cellular ligands for the activating NK cell receptor NKG2D. Up to now, three ligands for the NKG2D receptor, named RAE-1, H60, and MULT-1, have been identified in mice. The resistance of mouse strains to murine CMV (MCMV) infection is determined by their ability to generate an effective NK cell...
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