Article
Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response.
The Journal of experimental medicine - 16 Mar 2009
Kielczewska Agnieszka, Pyzik Michal, Sun Tianhe, Krmpotic Astrid, Lodoen Melissa B, Munks Michael W, Babic Marina, Hill Ann B, Koszinowski Ulrich H, Jonjic Stipan, Lanier Lewis L, Vidal Silvia M
Abstract excerpt
Natural killer (NK) cells are crucial in resistance to certain viral infections, but the mechanisms used to recognize infected cells remain largely unknown. Here, we show that the activating Ly49P receptor recognizes cells infected with mouse cytomegalovirus (MCMV) by a process that requires the presence of H2-D(k) and the MCMV m04 protein. Using H2 chimeras between H2-D(b) and -D(k), we demonstrate that the...
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