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Article

Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141.

Nature immunology - 1 Feb 2005

Tomasec Peter, Wang Eddie C Y, Davison Andrew J, Vojtesek Borivoj, Armstrong Melanie, Griffin Cora, McSharry Brian P, Morris Rebecca J, Llewellyn-Lacey Sian, Rickards Carole, Nomoto Akio, Sinzger Christian, Wilkinson Gavin W G

Abstract excerpt

Natural killer (NK) cells are crucial in the control of cytomegalovirus infections in mice and humans. Here we show that the viral UL141 gene product has an immunomodulatory function that is associated with low-passage strains of human cytomegalovirus. UL141 mediated efficient protection of cells against killing by a wide range of human NK cell populations, including interferon-alpha-stimulated bulk cultures,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15640804
DOI: 10.1038/ni1156
PMCID: PMC2844263

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141.PMID 15640804Read ↗

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