Article
NK cell activation through the NKG2D ligand MULT-1 is selectively prevented by the glycoprotein encoded by mouse cytomegalovirus gene m145.
The Journal of experimental medicine - 17 Jan 2005
Krmpotic Astrid, Hasan Milena, Loewendorf Andrea, Saulig Tanja, Halenius Anne, Lenac Tihana, Polic Bojan, Bubic Ivan, Kriegeskorte Anja, Pernjak-Pugel Ester, Messerle Martin, Hengel Hartmut, Busch Dirk H, Koszinowski Ulrich H, Jonjic Stipan
Abstract excerpt
The NK cell-activating receptor NKG2D interacts with three different cellular ligands, all of which are regulated by mouse cytomegalovirus (MCMV). We set out to define the viral gene product regulating murine UL16-binding protein-like transcript (MULT)-1, a newly described NKG2D ligand. We show that MCMV infection strongly induces MULT-1 gene expression, but surface expression of this glycoprotein is nevertheless...
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