Article
Reduced MCMV Δm157 viral clearance in the absence of TSAd.
Scientific reports - 18 Mar 2015
Moussa P, Abrahamsen G, Fodil N, Gopalakrishnan R P, Mancini M, Dissen E, Sæther P C, Wiltshire S A, Boivin G A, Caignard G, Spurkland A, Vidal S M
Abstract excerpt
The T cell specific adapter protein (TSAd) is expressed in activated T cells and NK cells. While TSAd is beginning to emerge as a critical regulator of Lck and Itk activity in T cells, its role in NK cells has not yet been explored. Here we have examined susceptibility to virus infections in a murine model using various viral infection models. We report that TSAd-deficient mice display reduced clearance of murine...
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