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Article

Modulation of ColE1-like plasmid replication for recombinant gene expression.

Recent patents on DNA & gene sequences - 1 Jan 2010

Camps Manel

Abstract excerpt

ColE1-like plasmids constitute the most popular vectors for recombinant protein expression. ColE1 plasmid replication is tightly controlled by an antisense RNA mechanism that is highly dynamic, tuning plasmid metabolic burden to the physiological state of the host. Plasmid homeostasis is upset upon induction of recombinant protein expression because of non-physiological levels of expression and because of the...

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Identifiers

PMID: 20218961
DOI: 10.2174/187221510790410822
PMCID: PMC2846101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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