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Article

Dimerization of plasmid DNA accelerates selection for antibiotic resistance.

Molecular microbiology - 1 Apr 1996

Mazin A V, Timchenko T V, Saparbaev M K, Mazina O M

Abstract excerpt

Dimerization of multicopy plasmids is widely assumed to be disadvantageous both for plasmid maintenance and for the host cell. It is known that dimerization causes plasmid instability; dimer-containing cells grow slower than their monomer-containing counterparts. However, as we demonstrate here, under conditions of selective stress, dimers provide an advantage for bacteria. Dimers facilitate segregation of...

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Source

Identifiers

PMID: 8861208
DOI: 10.1111/j.1365-2958.1996.tb02492.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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