Article
Dimerization of plasmid DNA accelerates selection for antibiotic resistance.
Molecular microbiology - 1 Apr 1996
Mazin A V, Timchenko T V, Saparbaev M K, Mazina O M
Abstract excerpt
Dimerization of multicopy plasmids is widely assumed to be disadvantageous both for plasmid maintenance and for the host cell. It is known that dimerization causes plasmid instability; dimer-containing cells grow slower than their monomer-containing counterparts. However, as we demonstrate here,...
Topics
- Ampicillin Resistance
- DNA, Bacterial
- Dimerization
- Escherichia coli
- Mutation
- R Factors
- Recombination, Genetic
- Tetracycline Resistance