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Article

Relaxation of replication control in chaperone-independent initiator mutants of plasmid P1.

The EMBO journal - 1 May 1994

Mukhopadhyay G, Sozhamannan S, Chattoraj D K

Abstract excerpt

Escherichia coli chaperones DnaJ, DnaK and GrpE increase P1 plasmid initiator binding to the origin by promoting initiator folding. The binding allows initiation and also promotes pairing of origins which is believed to control initiation frequency. Chaperone-independent DNA binding mutants are often defective in replication control. We show here that these mutants have increased rates of association for DNA...

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Identifiers

PMID: 7910558
DOI: 10.1002/j.1460-2075.1994.tb06484.x
PMCID: PMC395060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Relaxation of replication control in chaperone-independent initiator mutants of plasmid P1.PMID 7910558Read ↗

Participation of the Escherichia coli heat shock proteins DnaJ, DnaK, and GrpE in autorepression of the P1 plasmid repA promoter.Semantic proximity Read ↗

The DnaK-DnaJ-GrpE chaperone system activates inert wild type pi initiator protein of R6K into a form active in replication initiation.Semantic proximity Read ↗

Multiple homeostatic mechanisms in the control of P1 plasmid replication.Semantic proximity Read ↗

Chaperone-mediated reduction of RepA dimerization is associated with RepA conformational change.Semantic proximity Read ↗

Replication of the R6K gamma origin in vitro: dependence on wt pi and hyperactive piS87N protein variant.Semantic proximity Read ↗

Location of a P1 plasmid replication inhibitor determinant within the initiator gene.Semantic proximity Read ↗

Plasmid P1 RepA is homologous to the F plasmid RepE class of initiators.Semantic proximity Read ↗

Identification and characterization of a novel allele of Escherichia coli dnaB helicase that compromises the stability of plasmid P1.Semantic proximity Read ↗

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Mutagenesis reveals the complex relationships between ATPase rate and the chaperone activities of Escherichia coli heat shock protein 70 (Hsp70/DnaK).Semantic proximity Read ↗

Unique sequence requirements for the P1 plasmid replication origin.Semantic proximity Read ↗

The requirement for molecular chaperones in lambda DNA replication is reduced by the mutation pi in lambda P gene, which weakens the interaction between lambda P protein and DnaB helicase.Semantic proximity Read ↗

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