Relaxation of replication control in chaperone-independent initiator mutants of plasmid P1.

doi:10.1002/j.1460-2075.1994.tb06484.x

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Article

Relaxation of replication control in chaperone-independent initiator mutants of plasmid P1.

The EMBO journal - 1 May 1994

Mukhopadhyay G, Sozhamannan S, Chattoraj D K

Abstract excerpt

Escherichia coli chaperones DnaJ, DnaK and GrpE increase P1 plasmid initiator binding to the origin by promoting initiator folding. The binding allows initiation and also promotes pairing of origins which is believed to control initiation frequency. Chaperone-independent DNA binding mutants are o...

Topics

Bacterial Proteins
Chaperonins
DNA Helicases
DNA Replication
DNA, Bacterial
DNA-Binding Proteins
Escherichia coli
Kinetics
Mutation
Plasmids
Promoter Regions, Genetic
Protein Binding
Proteins
Trans-Activators

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