Article
Estimation of the source-by-source effect of autorepression on genetic noise.
Biophysical journal - 1 Aug 2008
Okano Hiroyuki, Kobayashi Tetsuya J, Tozaki Hirokazu, Kimura Hidenori
Abstract excerpt
Transcriptional autorepression has been thought to be one of the simplest control circuits to attenuate fluctuations in gene expression. Here, we explored the effect of autorepression on fluctuations from different noise sources. We theoretically represent the fluctuations in the copy number of proteins as the sum of several terms, each of which is related to a specific noise source and expressed as the product...
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