Imaging centromere-based incompatibilities: Insights into the mechanism of incompatibility mediated by low-copy number plasmids.

Abstract excerpt

In bacteria, low-copy number plasmids are faithfully segregated at cell division by active partition systems that rely on plasmid-specific centromere sequences. When an identical centromere is present on a second plasmid, faithful partition is impaired causing plasmid loss. Depending on the copy number of the co-resident replicon, several mechanisms have been proposed to account for this centromere-based plasmid...

Topics

• Centromere
• DNA Replication
• DNA, Bacterial
• Escherichia coli
• F Factor
• Gene Dosage
• Microscopy, Fluorescence
• Mutation