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Article

Not so different after all: a comparison of methods for detecting amino acid sites under selection.

Molecular biology and evolution - 1 May 2005

Kosakovsky Pond Sergei L, Frost Simon D W

Abstract excerpt

We consider three approaches for estimating the rates of nonsynonymous and synonymous changes at each site in a sequence alignment in order to identify sites under positive or negative selection: (1) a suite of fast likelihood-based "counting methods" that employ either a single most likely ancestral reconstruction, weighting across all possible ancestral reconstructions, or sampling from ancestral...

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PMID: 15703242
DOI: 10.1093/molbev/msi105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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