A Comparison of One-Rate and Two-Rate Inference Frameworks for Site-Specific dN/dS Estimation.

doi:10.1534/genetics.115.185264

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Article

A Comparison of One-Rate and Two-Rate Inference Frameworks for Site-Specific dN/dS Estimation.

Genetics - 1 Oct 2016

Spielman Stephanie J, Wan Suyang, Wilke Claus O

Abstract excerpt

Two broad paradigms exist for inferring [Formula: see text] the ratio of nonsynonymous to synonymous substitution rates, from coding sequences: (i) a one-rate approach, where [Formula: see text] is represented with a single parameter, or (ii) a two-rate approach, where [Formula: see text] and [Formula: see text] are estimated separately. The performances of these two approaches have been well studied in the...

Topics

Amino Acid Substitution
Computer Simulation
Evolution, Molecular
Genetic Variation
Mutation
Phylogeny
Selection, Genetic
Sequence Alignment

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Identifiers

PMID: 27535929
DOI: 10.1534/genetics.115.185264
PMCID: PMC5068842

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