Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Comparison of One-Rate and Two-Rate Inference Frameworks for Site-Specific dN/dS Estimation.

Genetics - 1 Oct 2016

Spielman Stephanie J, Wan Suyang, Wilke Claus O

Abstract excerpt

Two broad paradigms exist for inferring [Formula: see text] the ratio of nonsynonymous to synonymous substitution rates, from coding sequences: (i) a one-rate approach, where [Formula: see text] is represented with a single parameter, or (ii) a two-rate approach, where [Formula: see text] and [Formula: see text] are estimated separately. The performances of these two approaches have been well studied in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Computer Simulation
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Mutation

Share to Phylogeny

Share to Selection, Genetic

Share to Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 27535929
DOI: 10.1534/genetics.115.185264
PMCID: PMC5068842

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Comparison of One-Rate and Two-Rate Inference Frameworks for Site-Specific dN/dS Estimation.PMID 27535929Read ↗

The relationship between dN/dS and scaled selection coefficients.Semantic proximity Read ↗

Extensively Parameterized Mutation-Selection Models Reliably Capture Site-Specific Selective Constraint.Semantic proximity Read ↗

Evolutionary Shortcuts via Multinucleotide Substitutions and Their Impact on Natural Selection Analyses.Semantic proximity Read ↗

Evaluation of six methods for estimating synonymous and nonsynonymous substitution rates.Semantic proximity Read ↗

Why time matters: codon evolution and the temporal dynamics of dN/dS.Semantic proximity Read ↗

Site-to-site variation of synonymous substitution rates.Semantic proximity Read ↗

Not so different after all: a comparison of methods for detecting amino acid sites under selection.Semantic proximity Read ↗

The population genetics of dN/dS.Semantic proximity Read ↗

Large-scale analyses of synonymous substitution rates can be sensitive to assumptions about the process of mutation.Semantic proximity Read ↗

Statistical issues associated with modeling of synonymous mutation data.Semantic proximity Read ↗

Improved variance estimators for one- and two-parameter models of nucleotide substitution.Semantic proximity Read ↗

Evolutionary models accounting for layers of selection in protein-coding genes and their impact on the inference of positive selection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.