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Article

Detection of Regional Variation in Selection Intensity within Protein-Coding Genes Using DNA Sequence Polymorphism and Divergence.

Molecular biology and evolution - 1 Nov 2017

Zhao Zi-Ming, Campbell Michael C, Li Ning, Lee Daniel S W, Zhang Zhang, Townsend Jeffrey P

Abstract excerpt

Numerous approaches have been developed to infer natural selection based on the comparison of polymorphism within species and divergence between species. These methods are especially powerful for the detection of uniform selection operating across a gene. However, empirical analyses have demonstrated that regions of protein-coding genes exhibiting clusters of amino acid substitutions are subject to different...

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PMID: 28962009
DOI: 10.1093/molbev/msx213
PMCID: PMC5850860

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