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Article

Estimates of the effect of natural selection on protein-coding content.

Molecular biology and evolution - 1 Mar 2010

Yap Von Bing, Lindsay Helen, Easteal Simon, Huttley Gavin

Abstract excerpt

Analysis of natural selection is key to understanding many core biological processes, including the emergence of competition, cooperation, and complexity, and has important applications in the targeted development of vaccines. Selection is hard to observe directly but can be inferred from molecular sequence variation. For protein-coding nucleotide sequences, the ratio of nonsynonymous to synonymous substitutions...

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Identifiers

PMID: 19815689
DOI: 10.1093/molbev/msp232
PMCID: PMC2822286

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Source receipt: pubmed, retrieved 7 Sept 2026.

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