Article
Estimating the distribution of selection coefficients from phylogenetic data with applications to mitochondrial and viral DNA.
Molecular biology and evolution - 1 Aug 2003
Nielsen Rasmus, Yang Ziheng
Abstract excerpt
The distribution of selection coefficients of new mutations is of key interest in population genetics. In this paper we explore how codon-based likelihood models can be used to estimate the distribution of selection coefficients of new amino acid replacement mutations from phylogenetic data. To obtain such estimates we assume that all mutations at the same site have the same selection coefficient. We first...
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