Extensively Parameterized Mutation-Selection Models Reliably Capture Site-Specific Selective Constraint.

Abstract excerpt

The mutation-selection model of coding sequence evolution has received renewed attention for its use in estimating site-specific amino acid propensities and selection coefficient distributions. Two computationally tractable mutation-selection inference frameworks have been introduced: One framework employs a fixed-effects, highly parameterized maximum likelihood approach, whereas the other employs a...

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