Extensively Parameterized Mutation-Selection Models Reliably Capture Site-Specific Selective Constraint.

Abstract excerpt

The mutation-selection model of coding sequence evolution has received renewed attention for its use in estimating site-specific amino acid propensities and selection coefficient distributions. Two computationally tractable mutation-selection inference frameworks have been introduced: One framework employs a fixed-effects, highly parameterized maximum likelihood approach, whereas the other employs a...

Topics

• Amino Acid Substitution
• Amino Acids
• Bayes Theorem
• Evolution, Molecular
• Genetic Variation
• Likelihood Functions
• Models, Genetic
• Mutation
• Open Reading Frames
• Phylogeny
• Selection, Genetic