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Article

Detecting Selection in Noncoding Regions of Nucleotide Sequences

1 Jun 2004

Abstract excerpt

We present a maximum-likelihood method for examining the selection pressure and detecting positive selection in noncoding regions using multiple aligned DNA sequences. The rate of substitution in noncoding regions relative to the rate of synonymous substitution in coding regions is modeled by a parameter zeta. When a site in a noncoding region is evolving neutrally zeta = 1, while zeta > 1 indicates the action of...

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PMID: 15238543
DOI: 10.1534/genetics.102.010959

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