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Article

Functional interaction of wild-type and mutant p53 transfected into human tumor cell lines carrying activated ras genes.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Oct 1993

Sharma S, Schwarte-Waldhoff I, Oberhuber H, Schäfer R

Abstract excerpt

We have analyzed the antiproliferative activity of the p53 tumor suppressor gene in human tumor cell lines harboring activated ras genes. The levels of p53 protein and incorporation of bromodeoxyuridine in transiently transfected cells were determined simultaneously by flow cytometry. The human HT1080 fibrosarcoma, EJ bladder carcinoma, and SW480 colon carcinoma cell lines were equally sensitive toward wild-type...

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PMID: 8274455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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