Article
Functional interaction of wild-type and mutant p53 transfected into human tumor cell lines carrying activated ras genes.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Oct 1993
Sharma S, Schwarte-Waldhoff I, Oberhuber H, Schäfer R
Abstract excerpt
We have analyzed the antiproliferative activity of the p53 tumor suppressor gene in human tumor cell lines harboring activated ras genes. The levels of p53 protein and incorporation of bromodeoxyuridine in transiently transfected cells were determined simultaneously by flow cytometry. The human H...
Topics
- Amino Acids
- Base Sequence
- Cell Division
- DNA, Neoplasm
- Flow Cytometry
- Gene Expression
- Genes, ras
- Humans
- Molecular Sequence Data
- Mutation
- Precipitin Tests
- Reference Values
- Transfection
- Tumor Cells, Cultured