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Article

The N-terminal region of the Schizosaccharomyces pombe RecQ helicase, Rqh1p, physically interacts with Topoisomerase III and is required for Rqh1p function.

Molecular genetics and genomics : MGG - 1 Mar 2005

Ahmad Fouzia, Stewart Elspeth

Abstract excerpt

The Schizosaccharomyces pombe rqh1+ gene encodes a member of the RecQ DNA helicase family. Members of this protein family are essential for the maintenance of genetic integrity. Thus, mutations in the genes encoding the human RecQ homologues Blm, Wrn and RecQ4 cause Bloom syndrome, Werner syndrome and Rothmund-Thomson syndrome, respectively-diseases which result from genome instability. S. pombe cells that lack a...

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PMID: 15702347
DOI: 10.1007/s00438-005-1111-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The N-terminal region of the Schizosaccharomyces pombe RecQ helicase, Rqh1p, physically interacts with Topoisomerase III and is required for Rqh1p function.PMID 15702347Read ↗

Helicase activity is only partially required for Schizosaccharomyces pombe Rqh1p function.Semantic proximity Read ↗

Role for the fission yeast RecQ helicase in DNA repair in G2.Semantic proximity Read ↗

Topoisomerase III is required for accurate DNA replication and chromosome segregation in Schizosaccharomyces pombe.Semantic proximity Read ↗

The severe slow growth of Deltasrs2 Deltarqh1 in Schizosaccharomyces pombe is suppressed by loss of recombination and checkpoint genes.Semantic proximity Read ↗

The RecQ DNA helicase Rqh1 promotes Rad3 <sup>ATR</sup> kinase signaling in the DNA replication checkpoint pathway of fission yeastSemantic proximity Read ↗

Maintenance of Yeast Genome Integrity by RecQ Family DNA Helicases.Semantic proximity Read ↗

Human RECQ1 Is a DNA Damage Responsive Protein Required for Genotoxic Stress Resistance and Suppression of Sister Chromatid ExchangesSemantic proximity Read ↗

Requirement for Schizosaccharomyces pombe Top3 in the maintenance of chromosome integrity.Semantic proximity Read ↗

Topoisomerase III is essential for accurate nuclear division in Schizosaccharomyces pombe.Semantic proximity Read ↗

The fission yeast BLM homolog Rqh1 promotes meiotic recombination.Semantic proximity Read ↗

Function of recQ family helicase in genome stability.Semantic proximity Read ↗

A postsynaptic role for Rhp55/57 that is responsible for cell death in Deltarqh1 mutants following replication arrest in Schizosaccharomyces pombe.Semantic proximity Read ↗

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