Article
The N-terminal region of the Schizosaccharomyces pombe RecQ helicase, Rqh1p, physically interacts with Topoisomerase III and is required for Rqh1p function.
Molecular genetics and genomics : MGG - 1 Mar 2005
Ahmad Fouzia, Stewart Elspeth
Abstract excerpt
The Schizosaccharomyces pombe rqh1+ gene encodes a member of the RecQ DNA helicase family. Members of this protein family are essential for the maintenance of genetic integrity. Thus, mutations in the genes encoding the human RecQ homologues Blm, Wrn and RecQ4 cause Bloom syndrome, Werner syndrome and Rothmund-Thomson syndrome, respectively-diseases which result from genome instability. S. pombe cells that lack a...
Topics
- Adenosine Triphosphatases
- Blotting, Western
- DNA Damage
- DNA Helicases
- DNA Topoisomerases, Type I
- Hydroxyurea
- Immunoprecipitation
- Methyl Methanesulfonate
- Mutation
- Oligonucleotides
- Plasmids
- Protein Binding
- Protein Structure, Tertiary
- RecQ Helicases
- Schizosaccharomyces
- Schizosaccharomyces pombe Proteins
- Species Specificity
- Ultraviolet Rays