Article
Topoisomerase III is required for accurate DNA replication and chromosome segregation in Schizosaccharomyces pombe.
Nucleic acids research - 15 Sept 2002
Oh Misook, Choi In-Soon, Park Sang Dai
Abstract excerpt
The deletion of the top3(+) gene leads to defective nuclear division and lethality in Schizosaccharo myces pombe. This lethality is suppressed by concomitant loss of rqh1(+), the RecQ helicase. Despite extensive investigation, topoisomerase III function and its relationship with RecQ helicase remain poorly understood. We generated top3 temperature-sensitive (top3-ts) mutants and found these to be defective in...
Topics
- Cell Division
- Cell Nucleus
- Chromosome Segregation
- DNA Damage
- DNA Helicases
- DNA Replication
- DNA Topoisomerases, Type I
- Hydroxyurea
- Mutation
- Plasmids
- S Phase