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Article

Topoisomerase III is required for accurate DNA replication and chromosome segregation in Schizosaccharomyces pombe.

Nucleic acids research - 15 Sept 2002

Oh Misook, Choi In-Soon, Park Sang Dai

Abstract excerpt

The deletion of the top3(+) gene leads to defective nuclear division and lethality in Schizosaccharo myces pombe. This lethality is suppressed by concomitant loss of rqh1(+), the RecQ helicase. Despite extensive investigation, topoisomerase III function and its relationship with RecQ helicase remain poorly understood. We generated top3 temperature-sensitive (top3-ts) mutants and found these to be defective in...

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Identifiers

PMID: 12235386
DOI: 10.1093/nar/gkf531
PMCID: PMC137115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Topoisomerase III is required for accurate DNA replication and chromosome segregation in Schizosaccharomyces pombe.PMID 12235386Read ↗

Requirement for Schizosaccharomyces pombe Top3 in the maintenance of chromosome integrity.Semantic proximity Read ↗

Topoisomerase III is essential for accurate nuclear division in Schizosaccharomyces pombe.Semantic proximity Read ↗

The N-terminal region of the Schizosaccharomyces pombe RecQ helicase, Rqh1p, physically interacts with Topoisomerase III and is required for Rqh1p function.Semantic proximity Read ↗

The top3(+) gene is essential in Schizosaccharomyces pombe and the lethality associated with its loss is caused by Rad12 helicase activity.Semantic proximity Read ↗

Topoisomerase III acts upstream of Rad53p in the S-phase DNA damage checkpoint.Semantic proximity Read ↗

Role for the fission yeast RecQ helicase in DNA repair in G2.Semantic proximity Read ↗

Helicase activity is only partially required for Schizosaccharomyces pombe Rqh1p function.Semantic proximity Read ↗

Top3 processes recombination intermediates and modulates checkpoint activity after DNA damage.Semantic proximity Read ↗

Inactivation of homologous recombination suppresses defects in topoisomerase III-deficient mutants.Semantic proximity Read ↗

Human TopBP1 Ensures Genome Integrity during Normal S PhaseSemantic proximity Read ↗

Mutations in homologous recombination genes rescue top3 slow growth in Saccharomyces cerevisiae.Semantic proximity Read ↗

The severe slow growth of Deltasrs2 Deltarqh1 in Schizosaccharomyces pombe is suppressed by loss of recombination and checkpoint genes.Semantic proximity Read ↗

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