Article
A postsynaptic role for Rhp55/57 that is responsible for cell death in Deltarqh1 mutants following replication arrest in Schizosaccharomyces pombe.
Genetics - 1 Jun 2005
Hope Justin C, Maftahi Mohamed, Freyer Greg A
Abstract excerpt
Following replication arrest, multiple cellular responses are triggered to maintain genomic integrity. In fission yeast, the RecQ helicase, Rqh1, plays a critical role in this process. This is demonstrated in Deltarqh1 cells that, following treatment with hydroxyurea (HU), undergo an aberrant mitosis leading to cell death. Previous data suggest that Rqh1 functions with homologous recombination (HR) in recovery...
Topics
- Adenosine Triphosphatases
- Cell Death
- DNA Damage
- DNA Helicases
- DNA-Binding Proteins
- Dose-Response Relationship, Drug
- Dose-Response Relationship, Radiation
- Electrophoresis, Gel, Pulsed-Field
- Genetic Complementation Test
- Genotype
- Hydroxyurea
- Mitosis
- Models, Genetic