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Article

Requirement for Schizosaccharomyces pombe Top3 in the maintenance of chromosome integrity.

Journal of cell science - 15 Sept 2004

Win Thein Z, Goodwin Adele, Hickson Ian D, Norbury Chris J, Wang Shao-Win

Abstract excerpt

In Schizosaccharomyces pombe, topoisomerase III is encoded by a single gene, top3(+), which is essential for cell viability and proper chromosome segregation. Deletion of rqh1(+), which encodes the sole RecQ family helicase in S. pombe, suppresses the lethality caused by loss of top3. Here, we provide evidence suggesting that the lethality in top3 mutants is due to accumulation of aberrant DNA structures that...

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Identifiers

PMID: 15340008
DOI: 10.1242/jcs.01351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Requirement for Schizosaccharomyces pombe Top3 in the maintenance of chromosome integrity.PMID 15340008Read ↗

Topoisomerase III is required for accurate DNA replication and chromosome segregation in Schizosaccharomyces pombe.Semantic proximity Read ↗

Topoisomerase III is essential for accurate nuclear division in Schizosaccharomyces pombe.Semantic proximity Read ↗

Top3 processes recombination intermediates and modulates checkpoint activity after DNA damage.Semantic proximity Read ↗

Topoisomerase III acts upstream of Rad53p in the S-phase DNA damage checkpoint.Semantic proximity Read ↗

The top3(+) gene is essential in Schizosaccharomyces pombe and the lethality associated with its loss is caused by Rad12 helicase activity.Semantic proximity Read ↗

Inactivation of homologous recombination suppresses defects in topoisomerase III-deficient mutants.Semantic proximity Read ↗

Mutations in homologous recombination genes rescue top3 slow growth in Saccharomyces cerevisiae.Semantic proximity Read ↗

The essential role of yeast topoisomerase III in meiosis depends on recombination.Semantic proximity Read ↗

A mitotic topoisomerase II checkpoint in budding yeast is required for genome stability but acts independently of Pds1/securin.Semantic proximity Read ↗

Monitoring the DNA Topoisomerase II Checkpoint in Saccharomyces cerevisiae.Semantic proximity Read ↗

The N-terminal region of the Schizosaccharomyces pombe RecQ helicase, Rqh1p, physically interacts with Topoisomerase III and is required for Rqh1p function.Semantic proximity Read ↗

Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: a gene required for the DNA damage checkpoint but not the replication checkpoint.Semantic proximity Read ↗

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