Article

The RecQ DNA helicase Rqh1 promotes Rad3 <sup>ATR</sup> kinase signaling in the DNA replication checkpoint pathway of fission yeast

2020-04-11

Abstract excerpt

<h4>ABSTRACT</h4> Rad3 is the orthologue of ATR and the sensor kinase of the DNA replication checkpoint in Schizosaccharomyces pombe . Under replication stress, it initiates checkpoint signaling at the forks necessary for maintaining genome stability and cell survival. To better understand the checkpoint initiation process, we have carried out a genetic screen in fission yeast by random mutation of the genome lo...

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Literature Corpus work: 3eecb6e6-bd8a-547f-8375-4262c95d9f15
DOI: 10.1101/2020.04.10.036707

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