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Article

The severe slow growth of Deltasrs2 Deltarqh1 in Schizosaccharomyces pombe is suppressed by loss of recombination and checkpoint genes.

Nucleic acids research - 1 Nov 2002

Maftahi Mohamed, Hope Justin C, Delgado-Cruzata Lissette, Han Christine S, Freyer Greg A

Abstract excerpt

Our interest in the Schizosaccharomyces pombe RecQ helicase, rqh1+, led us to investigate the function of a related putative DNA helicase, srs2+. We identified the srs2+ homolog in S.pombe, and found that srs2+ is not essential for cell viability. A Deltasrs2 Deltarqh1 double mutant grows extremely slowly with aberrant shaped cells and low viability. This slow growth does not appear to be related to stalled...

Topics

Cell Cycle
DNA Helicases
DNA Replication
Gene Deletion
Genes, Fungal
Genes, Lethal
Genes, cdc
Hydroxyurea
Phenotype
Recombination, Genetic
Schizosaccharomyces

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Schizosaccharomyces pombe Proteins

Sequence Homology, Nucleic Acid

Suppression, Genetic

Ultraviolet Rays

Source

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Identifiers

PMID: 12409469
DOI: 10.1093/nar/gkf581
PMCID: PMC135788

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The severe slow growth of Deltasrs2 Deltarqh1 in Schizosaccharomyces pombe is suppressed by loss of recombination and checkpoint genes.PMID 12409469Read ↗

Involvement of Schizosaccharomyces pombe Srs2 in cellular responses to DNA damage.Semantic proximity Read ↗

Helicase activity is only partially required for Schizosaccharomyces pombe Rqh1p function.Semantic proximity Read ↗

A postsynaptic role for Rhp55/57 that is responsible for cell death in Deltarqh1 mutants following replication arrest in Schizosaccharomyces pombe.Semantic proximity Read ↗

Role of the Schizosaccharomyces pombe F-Box DNA helicase in processing recombination intermediates.Semantic proximity Read ↗

The N-terminal region of the Schizosaccharomyces pombe RecQ helicase, Rqh1p, physically interacts with Topoisomerase III and is required for Rqh1p function.Semantic proximity Read ↗

Redundant roles of Srs2 helicase and replication checkpoint in survival and rDNA maintenance in Schizosaccharomyces pombe.Semantic proximity Read ↗

Role for the fission yeast RecQ helicase in DNA repair in G2.Semantic proximity Read ↗

Role of Schizosaccharomyces pombe RecQ homolog, recombination, and checkpoint genes in UV damage tolerance.Semantic proximity Read ↗

Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint.Semantic proximity Read ↗

The RecQ DNA helicase Rqh1 promotes Rad3 <sup>ATR</sup> kinase signaling in the DNA replication checkpoint pathway of fission yeastSemantic proximity Read ↗

Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases.Semantic proximity Read ↗

Novel pof1 mutation suppresses the sensitivity to DNA replication inhibitor in fission yeast RecQ helicase mutant.Semantic proximity Read ↗

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