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Article

The severe slow growth of Deltasrs2 Deltarqh1 in Schizosaccharomyces pombe is suppressed by loss of recombination and checkpoint genes.

Nucleic acids research - 1 Nov 2002

Maftahi Mohamed, Hope Justin C, Delgado-Cruzata Lissette, Han Christine S, Freyer Greg A

Abstract excerpt

Our interest in the Schizosaccharomyces pombe RecQ helicase, rqh1+, led us to investigate the function of a related putative DNA helicase, srs2+. We identified the srs2+ homolog in S.pombe, and found that srs2+ is not essential for cell viability. A Deltasrs2 Deltarqh1 double mutant grows extremely slowly with aberrant shaped cells and low viability. This slow growth does not appear to be related to stalled...

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Identifiers

PMID: 12409469
DOI: 10.1093/nar/gkf581
PMCID: PMC135788

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Research trail→

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The severe slow growth of Deltasrs2 Deltarqh1 in Schizosaccharomyces pombe is suppressed by loss of recombination and checkpoint genes.PMID 12409469Read ↗

Involvement of Schizosaccharomyces pombe Srs2 in cellular responses to DNA damage.Semantic proximity Read ↗

Helicase activity is only partially required for Schizosaccharomyces pombe Rqh1p function.Semantic proximity Read ↗

A postsynaptic role for Rhp55/57 that is responsible for cell death in Deltarqh1 mutants following replication arrest in Schizosaccharomyces pombe.Semantic proximity Read ↗

Role of the Schizosaccharomyces pombe F-Box DNA helicase in processing recombination intermediates.Semantic proximity Read ↗

The N-terminal region of the Schizosaccharomyces pombe RecQ helicase, Rqh1p, physically interacts with Topoisomerase III and is required for Rqh1p function.Semantic proximity Read ↗

Redundant roles of Srs2 helicase and replication checkpoint in survival and rDNA maintenance in Schizosaccharomyces pombe.Semantic proximity Read ↗

Role for the fission yeast RecQ helicase in DNA repair in G2.Semantic proximity Read ↗

Role of Schizosaccharomyces pombe RecQ homolog, recombination, and checkpoint genes in UV damage tolerance.Semantic proximity Read ↗

Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint.Semantic proximity Read ↗

The RecQ DNA helicase Rqh1 promotes Rad3 <sup>ATR</sup> kinase signaling in the DNA replication checkpoint pathway of fission yeastSemantic proximity Read ↗

Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases.Semantic proximity Read ↗

Novel pof1 mutation suppresses the sensitivity to DNA replication inhibitor in fission yeast RecQ helicase mutant.Semantic proximity Read ↗

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