Article
Helicase activity is only partially required for Schizosaccharomyces pombe Rqh1p function.
Yeast (Chichester, England) - 1 Dec 2002
Ahmad Fouzia, Kaplan Craig D, Stewart Elspeth
Abstract excerpt
The RecQ-related family of DNA helicases is required for the maintenance of genomic stability in organisms ranging from bacteria to humans. In humans, mutation of three RecQ-related helicases, BLM, WRN and RecQL4, cause the cancer-prone and premature ageing diseases of Bloom syndrome, Werner's syndrome and Rothmund-Thompson syndrome, respectively. In the fission yeast Schizosaccharomyces pombe, disruption of the...
Topics
- Adenosine Triphosphate
- Binding Sites
- Chromosome Deletion
- Chromosome Segregation
- DNA Damage
- DNA Helicases
- DNA, Fungal
- Fungal Proteins
- Mutation
- S Phase
- Schizosaccharomyces