Article
Ran GTPase regulates Mad2 localization to the nuclear pore complex.
Eukaryotic cell - 1 Feb 2005
Quimby B Booth, Arnaoutov Alexei, Dasso Mary
Abstract excerpt
In yeast and mammalian cells, the spindle assembly checkpoint proteins Mad1p and Mad2p localize to the nuclear pore complex (NPC) during interphase. Deletion of MAD1 or MAD2 did not affect steady-state nucleocytoplasmic distribution of a classical nuclear localization signal-containing reporter, a nuclear export signal-containing reporter, or Ran localization. We utilized cells with conditional mutations in the...
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