Article
The karyopherin Kap95 regulates nuclear pore complex assembly into intact nuclear envelopes in vivo.
Molecular biology of the cell - 1 Mar 2007
Ryan Kathryn J, Zhou Yingna, Wente Susan R
Abstract excerpt
Nuclear pore complex (NPC) assembly in interphase cells requires that new NPCs insert into an intact nuclear envelope (NE). Our previous work identified the Ran GTPase as an essential component in this process. We proposed that Ran is required for targeting assembly factors to the cytoplasmic NE face via a novel, vesicular intermediate. Although the molecular target was not identified, Ran is known to function by...
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