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Article

Crm1 is a mitotic effector of Ran-GTP in somatic cells.

Nature cell biology - 1 Jun 2005

Arnaoutov Alexei, Azuma Yoshiaki, Ribbeck Katharina, Joseph Jomon, Boyarchuk Yekaterina, Karpova Tatiana, McNally James, Dasso Mary

Abstract excerpt

The Ran GTPase controls multiple cellular processes, including nuclear transport, mitotic checkpoints, spindle assembly and post-mitotic nuclear envelope reassembly. Here we examine the mitotic function of Crm1, the Ran-GTP-binding nuclear export receptor for leucine-rich cargo (bearing nuclear export sequence) and Snurportin-1 (ref. 3). We find that Crm1 localizes to kinetochores, and that Crm1 ternary complex...

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PMID: 15908946
DOI: 10.1038/ncb1263

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