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Article

Allelic genes involved in artery compliance and susceptibility to sporadic abdominal aortic aneurysm.

The Journal of steroid biochemistry and molecular biology - 1 Dec 2004

Massart Francesco, Marini Francesca, Menegato Alessandra, Del Monte Francesca, Nuti Marco, Butitta Flavio, Ferrari Mauro, Balbarini Alberto, Brandi Maria Luisa

Abstract excerpt

Vascular smooth muscle cells (VSMCs) synthesize elastin (ELN), major protein of aortic tunica media which confers strength and elasticity to aortic wall. Protein loss or distortion is typical in aneurysm tunica media. Transforming growth factor beta1 (TGFbeta1) inhibits growth and connective protein expression of abdominal VSMCs cultures. Also, in atherogenic studies, estrogen (but not estrogen plus progestin)...

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Share to Aortic Aneurysm, Abdominal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

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Share to Receptors, Progesterone

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Source

Identifiers

PMID: 15698546
DOI: 10.1016/j.jsbmb.2004.10.010

Genes

ELN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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